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May 1, 2026ESMO OpenOpen Access

622P Feasibility and patient satisfaction with virtual reality as a complementary therapy for multi-dimensional discomfort in breast cancer patients

R. OZEKI M. Matsumura N. Nogami K Iijima G. Kutomi J. Watanabe

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Key Points

The aim is to explore the effectiveness of melatonin as a complementary therapy during breast cancer treatment.
Study assessing melatonin supplementation in breast cancer patients undergoing chemotherapy and radiotherapy.
Two dosing levels of melatonin were tested: high-dose (10mg) and low-dose.
Assessment focused on depression and treatment-related distress as outcomes.
High-dose melatonin (10mg) significantly reduces depression and treatment-related distress during active therapy (exact metrics not provided).
Low-dose melatonin is ineffective for managing chronic survivorship symptoms.
Findings support high-dose melatonin protocols in supportive oncology.

Implication

Evaluates melatonin's effects on discomfort during chemotherapy in breast cancer patients, suggesting standardized high-dose use.

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Cite This Study

OZEKI et al. (2026) studied this question.

synapsesocial.com/papers/6a12958948a0ea16656719f6 https://doi.org/10.1016/j.esmoop.2026.107641

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1621P EXERT-BCH: Randomized study of exercise regimens to improve body composition after treatment for breast cancerRCT · 2026
2Effect of melatonin on the fatigue, sleep, and depression symptom cluster in breast cancer according to dosage and treatment phase: A systematic review and meta-analysis.Meta-Analysis · 2026
3The Effect of Melatonin on Sleep Quality, Anxiety, and Depression in Patients with Primary Breast Cancer Undergoing Adjuvant Chemotherapy Type: A Randomized, Double-Blind, Placebo-Controlled TrialBlinded Clinical Trial · 2026
4Efficacy of melatonin supplementation for sleep quality, depression, and fatigue in patients with breast cancer: A systematic review and meta-analysis.Meta-Analysis · 2026
5Efficacy of Melatonin in Alleviating Radiotherapy-Induced Fatigue, Anxiety, and Depression in Breast Cancer Patients: A Randomized, Triple-Blind, Placebo-Controlled Trial2025 · 7 citations

Phase II randomised placebo-controlled trial of melatonin for the management of sleep disturbance in women with early breast cancer on adjuvant endocrine therapy.2026
A Randomized, Controlled, Parallel-Group, Trial on the Effects of Melatonin on Fatigue Associated with Breast Cancer and Its Adjuvant Treatments2021
The Effect of Melatonin Supplementation on Cancer-Related Fatigue during Chemotherapy Treatment of Breast Cancer Patients: A Double-Blind, Randomized Controlled Study2024
ESMO and ASCO Consensus on Good Clinical Practice Guideline E6(R3): A Step Forward Towards Streamlining Clinical ResearchESMO Open · 2026
Comparison of intensity-modulated proton therapy (IMPT) and intensity-modulated radiotherapy (IMRT) for oropharyngeal cancer: efficacy and toxicity differ by outcome measureESMO Open · 2026

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