A Sulfonated Diblock Copolymer Exhibits Reversible Antiplatelet Activity and Enables Aqueous Dipyridamole Formulation

A. FRACKIEWICZ; Karol Depczynski; Magdalena Obłoza; 遊佐 真一; Altangerel Amarjargal; Amir Fahmi; Dariusz Pawlak; Krzysztof Szczubiałka; Andrzej Mogielnicki; Bartłomiej Kałaska

doi:10.1039/d6bm00269b

January 1, 2026Biomaterials Science

A Sulfonated Diblock Copolymer Exhibits Reversible Antiplatelet Activity and Enables Aqueous Dipyridamole Formulation

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Key Points

This research aims to investigate the antiplatelet activity of a sulfonated diblock copolymer and its potential for drug formulation.
Utilized poly(sodium styrene sulfonate)-poly(sodium acrylamido undecanoate) as a diblock copolymer.
Examined the charge-mediated inhibition of platelet function.
Assessed aqueous formulation properties of dipyridamole.
The diblock copolymer demonstrated intrinsic platelet inhibition via charge interactions.
Reversible inhibition suggests potential for controlled drug delivery.
Enabled formulation of dipyridamole in aqueous conditions.

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Implication

Reports reversible antiplatelet effects in a novel copolymer, suggesting new drug formulations.

Abstract

Sulfonated block copolymers modulate biological function via charge-charge interactions. We report a sulfonated diblock copolymer - poly(sodium styrene sulfonate)-poly(sodium acrylamido undecanoate) (PSSNa 38 - b -PAaU 10 ) with intrinsic charge-mediated platelet inhibition, and externally triggered...

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FRACKIEWICZ et al. (2026) studied this question.

synapsesocial.com/papers/6a12959d48a0ea1665671ae5 https://doi.org/10.1039/d6bm00269b

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A Sulfonated Diblock Copolymer Exhibits Reversible Antiplatelet Activity and Enables Aqueous Dipyridamole Formulation

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Abstract

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A Sulfonated Diblock Copolymer Exhibits Reversible Antiplatelet Activity and Enables Aqueous Dipyridamole Formulation

Key Points

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Implication

Abstract

Discussion

Cite This Study

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