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May 24, 2026Asian Pacific Journal of Cancer PreventionOpen Access

A Novel Circulating microRNA Signature Panel as a Prognostic Biomarker for in Patients with Colorectal Cancer

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Authors

NDNoha Bader El DinSFSally FaroukREReem El-Shenawy

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Overview

Randomized trial identifies a microRNA panel that predicts outcomes in colorectal cancer patients, suggesting improved screening.

Key Points

  • This study aims to establish a circulating microRNA signature panel that accurately predicts prognosis in colorectal cancer patients.
  • Conducted in two independent stages with 225 subjects (150 CRC patients, 75 controls).
  • Evaluated expression of 25 selected microRNAs and confirmed significant findings in validation group (160 subjects).
  • Applied qRT-PCR analysis for microRNA measurement and assessed prognostic performance through AUC and specificity metrics.
  • Eight miRNAs significantly higher in CRC patients, achieving an AUC of 0.92 and specificity of 99.73%.
  • A combination of five miRNAs resulted in an AUC of 0.97 with a specificity of 99.6%.
  • The highest AUC (0.974) and specificity (99.27%) were observed with three miRNAs (miR-21, miR-26a, miR-26b).

Cite This Study

Din et al. (2026) studied this question.

synapsesocial.com/papers/6a1295ae48a0ea1665671e52https://doi.org/10.31557/apjcp.2026.27.5.1735
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