Randomized trial compares dosimetric effects of hypofractionated and conventional VMAT in left breast cancer, indicating possible advantages of hypofractionation.
Key Points
This study aims to evaluate dosimetric and radiobiological benefits of hypofractionated versus conventional VMAT for left breast cancer after surgery.
Included 24 patients with confirmed left breast cancer aged 42-68 years.
Divided into two groups: 12 received conventional (50 Gy in 25 fractions) and 12 hypofractionated (40 Gy in 15 fractions) regimens.
Compared dosimetric parameters like clinical target volume coverage, homogeneity index, conformity index, and dose to organs at risk.
Both treatment plans showed excellent target coverage, with no significant differences in conformity index.
Hypofractionated approach reduced mean heart dose by 28.7% (6.24 Gy vs. 8.91 Gy) and significantly lowered dose to contralateral lung (5.62 Gy vs. 7.32 Gy; p = 0.029).