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May 24, 2026Open Access

PrEP awareness and engagement among transgender women in South Africa: a cross-sectional, mixed methods study

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HCHuman Sciences Research Council

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Overview

Cross-sectional study explores PrEP awareness and barriers in transgender women, suggesting improved education for better uptake.

Key Points

  • The study aims to explore PrEP awareness, uptake, willingness, and barriers among transgender women in South Africa.
  • Cross-sectional, mixed methods design with community-engaged data collectors
  • 213 transgender women participants recruited via network referral
  • Quantitative analysis with descriptive statistics and negative binomial regression; qualitative interviews with thematic content analysis.
  • 45% of HIV-negative participants were PrEP-aware, while only 11% were currently taking it.
  • Willingness to take PrEP was 55%, negatively associated with community connectedness.
  • Barriers identified included daily pill intake, side effects, and costs.

Cite This Study

Human Sciences Research Council (2026) studied this question.

synapsesocial.com/papers/6a1295cf48a0ea1665672297https://doi.org/10.14749/32378436
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