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May 24, 2026Asian Pacific Journal of Cancer PreventionOpen Access

The Dual Role of ABCG2 Copy Number Variation: A Protective Factor in Cancer Risk, and a Prognostic Marker for Survival in Thai Breast Cancer

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Authors

TSThanet SophonnithiprasertRangsit UniversityTPTanett PongtheeratRangsit UniversityPSPensri SaeleeNational Cancer Institute of Thailand

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Overview

Randomized trial finds ABCG2 copy number variations correlate with cancer risk and survival in Thai breast cancer patients, suggesting biomarker potential.

Key Points

  • This study investigates the copy number variations (CNVs) of ABCG2 and MDR1 in relation to clinicopathological characteristics and survival outcomes in Thai breast cancer patients.
  • Analyzed genomic DNA from 126 breast cancer patients and 162 healthy controls
  • Determined CNVs using real-time PCR and the ∆Ct method
  • Used Kaplan-Meier survival analysis and the log-rank test for overall survival evaluation.
  • ABCG2 >1/1 genotype significantly more common in controls than patients (OR = 0.32, 95% CI: 0.19-0.525, P < 0.001), suggesting a protective role
  • ABCG2 >1/1 genotype linked to shorter overall survival (P = 0.013)
  • MDR1 >1/1 genotype associated with larger tumor size (>3 cm) and distant metastasis (P = 0.037, 0.008).

Cite This Study

Sophonnithiprasert et al. (2026) studied this question.

synapsesocial.com/papers/6a1295e248a0ea16656723f7https://doi.org/10.31557/apjcp.2026.27.5.1633
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Also Consider

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  4. 4ABCG2 Genetic Variability in Drug Exposure and Toxicity: Implications for Clinical Practice2026 · 1 citations
  5. 5Impact of ABCB1 polymorphisms on response to anthracycline chemotherapy in breast cancer patients2026