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May 24, 2026Chemical Communications

Enantiodivergent Rh III -Catalyzed Synthesis of Imidazo1,5-aindole

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Authors

MBMarimuthu BakkiyarajPAPazhamalai Anbarasan

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Overview

Randomized trial demonstrates efficient synthesis of imidazo[1,5-a]indole, suggesting promising methods in organic chemistry.

Key Points

  • The aim is to develop an efficient method for synthesizing imidazo[1,5-a]indole using a rhodium catalyst.
  • Utilized a chiral cyclopentadienyl rhodium catalyst for the reaction.
  • Performed [4+1]-annulation of indole-N-carboxamide with cyclopropene.
  • Investigated the introduction of bulky substituents on the product.
  • Successfully achieved a general and efficient synthesis of imidazo[1,5-a]indole.
  • The presence of a bulky substituent enhanced the enantiodivergence of the reaction.

Cite This Study

Bakkiyaraj et al. (2026) studied this question.

synapsesocial.com/papers/6a12964948a0ea1665673044https://doi.org/10.1039/d6cc01074a
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