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May 24, 2026GeroScienceOpen Access

Skin as a sentinel and modulator of systemic aging: a translational framework for evidence-based gerotherapeutics

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Authors

DHDiala HaykalFFFrederic Flament

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Overview

Translational framework examines skin as a modulator of aging to enhance gerotherapeutic outcomes.

Key Points

  • This research explores how skin can serve as a measurable marker of aging and a target for therapeutic interventions.
  • Evaluated age-related changes in skin through in vivo observations and sampling.
  • Examined biomarkers and functional endpoints to support aging interventions.
  • Considered non-invasive technologies for monitoring skin changes longitudinally.
  • Identified intrinsic aging mechanisms affecting skin and their systemic implications.
  • Highlighted the role of skin dysfunction in systemic aging via inflammatory and immune signaling.
  • Outlined the importance of aligning interventions with varied aging trajectories using skin indicators.

Cite This Study

Haykal et al. (2026) studied this question.

synapsesocial.com/papers/6a12969048a0ea166567367chttps://doi.org/10.1007/s11357-026-02331-7
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