Research progress of brain injury after cardiopulmonary resuscitation

With the development of cardiopulmonary resuscitation technology, the success rate of treatment in patients with cardiac arrest has improved. However, the therapeutic effect on brain injury after cardiopulmonary resuscitation is unsatisfactory. To provide a reference for the research and treatment of postresuscitation brain injury, this study summarizes the latest research progress on the mechanisms of postresuscitation brain injury (such as classical mechanism-mediated brain injury, extracellular vesicle-mediated brain injury, and distal organ dysfunction-mediated brain injury), neurological function assessment (neurological examination, serum biomarkers, electroencephalography, multimodal evaluation, etc.), and clinical treatment (strategies of ventilation and oxygen therapy, targeted temperature management, drug therapy, etc.) by reviewing the literature and combining the relevant research findings of our research group.