Elevated symmetric dimethylarginine (SDMA) levels were independently associated with an increased risk of developing severe in-hospital heart failure (OR 8.2) in patients with acute myocardial infarction.
Cross-Sectional (n=487)
No
Does elevated symmetric dimethylarginine (SDMA) predict in-hospital severe heart failure and death in patients with acute myocardial infarction?
Elevated SDMA levels on admission in patients with acute myocardial infarction are independently associated with an increased risk of developing in-hospital severe heart failure and mortality.
Effect estimate: OR 8.2 (95% CI 3.0-22.5)
Absolute Event Rate: 7.4% vs 0.6%
p-value: p=<0.001
OBJECTIVES: We aimed to investigate whether SDMA- symmetric dimethylarginine -the symmetrical stereoisomer of ADMA- might be a marker of left ventricular function in AMI. BACKGROUND: Asymmetric dimethylarginine (ADMA) has been implicated in the prognosis after acute myocardial infarction (AMI) and heart failure (HF). METHODS: Cross sectional prospective study from 487 consecutive patients hospitalized 2, and death. RESULTS: Patients were analysed based on SDMA tertiles. Sex, diabetes, dyslipidemia, and prior MI were similar for all tertiles. In contrast, age and hypertension increased across the tertiles (p<0.001). From the first to the last tertile, GRACE risk score was elevated while LVEF and eGFR was reduced. The rate of severe HF and death were gradually increased across the SDMA tertiles (from 0.6% to 7.4%, p = 0.006 and from 0.6% to 5.0%, p = 0.034, respectively). Backward logistic multivariate analysis showed that SDMA was an independent estimate of developing severe HF, even when adjusted for confounding (OR(95%CI): 8.2(3.0-22.5), p<0.001). Further, SDMA was associated with mortality, even after adjustment for GRACE risk score (OR(95%CI): 4.56(1.34-15.52), p = 0.015). CONCLUSIONS: Our study showed for the first time that SDMA is associated with hospital outcomes, through altered LVEF and may have biological activity beyond renal function.
Lorin et al. (Thu,) conducted a cross-sectional in Acute Myocardial Infarction (n=487). Elevated Symmetric Dimethylarginine (SDMA) vs. Lower SDMA levels was evaluated on In-hospital severe heart failure (Killip class >2) (OR 8.2, 95% CI 3.0-22.5, p=<0.001). Elevated symmetric dimethylarginine (SDMA) levels were independently associated with an increased risk of developing severe in-hospital heart failure (OR 8.2) in patients with acute myocardial infarction.