Orbitofrontal cortex connectivity is associated with food reward and body weight in humans

Figures

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  Fig. 3.. The resting-state functional connectivities involving the OFC are higher relative to other functional connectivities in the high BMI group than the mid BMI group in the HCPt dataset. For the HCP dataset, the t values for the resting-state functional connectivity differences for the high BMI minus the mid BMI participants are shown, with age, gender, education years, drinking status, smoking status and head motion regressed out. The areas referred to are olfactory (an area just posterior to the OFC in the AAL2 atlas) to the lateral OFC (OFClat) in the AAL2 atlas, and their connectivities with all other brain areas are within the red rectangles. The BMI groups and the numbers of participants in each are shown in Figure 5. The statistics are provided in the text and compared connectivities within the red rectangles for olfactory to OFClat with those outside the red rectangles.

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  Fig. 5.. High BMI is associated with low mean functional connectivity. The relation between the mean FC across all cortical areas for the three groups with different BMI for the HCP. The high BMI group has a lower mean functional connectivity compared to the mid BMI group (t = −2.9, Cohen’s d = −0.13, df = 460, P = 4.3 × 10−3), with age, gender, education years, drinking status, smoking status and head motion regressed out. The numbers of participants in each group are shown.

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  Fig. 1.. The liking for sweet foods is correlated with functional connectivities of the VMPFC (in this case gyrus rectus, FrontalMedOrb and FrontalSupMed from the AAL2 atlas). For the UK Biobank, the correlation between the ‘liking for sweet foods’ and the resting-state functional connectivities between all AAL2 brain areas. The lower left triangle shows the Pearson’s correlations with the 94 × 94 functional connectivities, and the upper right triangle shows those that were significantly higher after FDR correction (P < 0.05 with a two-tailed test). A list of the AAL2 areas and their abbreviations is provided in Supplementary Table S1. Frontal_Med_Orb with Rectus corresponds to the VMPFC and Frontal_Sup_Medial includes cortex just superior to this. The OFC areas are OFCmed to OFClat. There were 37 286 participants.

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  Fig. 2.. BMI is correlated with functional connectivities of the VMPFC and anterior OFC (OFCant from the AAL2 atlas). For the UK Biobandatak, the correlation between the BMI and the resting-state functional connectivities between all AAL2 brain areas. The lower left triangle shows the Pearson’s correlations with the 94 × 94 functional connectivities, and the upper right triangle shows those that were significantly higher after FDR correction (P < 0.05 with a two-tailed test). There were 37 286 participants.

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  Fig. 4.. The resting-state functional connectivities involving the OFC are lower relative to other functional connectivities in the low BMI group than the mid BMI group in the HCP dataset. For the HCP dataset, the t values for the resting-state functional connectivity differences for the low BMI minus the mid BMI participants are shown, with age, gender, education, drinking frequency, smoking status and head motion regressed out. The areas referred to are anterior OFC (OFCant) to lateral OFC (OFClat) in the AAL2 atlas, and their connectivities with all other brain areas are within the red rectangles. The BMI groups and the numbers of participants in each are shown in Figure 5. The statistics are provided in the text and compared connectivities within the red rectangles for OFCant to OFClat with those outside the red rectangles.