Global Functional Connectivity at Rest Is Associated with Attention: An Arterial Spin Labeling Study

Figures

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  Figure A1. Correlation of resting-state functional connectivity with P3 properties after FWE correction. Resting-state functional connectivity, measured with rsDASL, was significantly correlated with P3 amplitude after FWE correction (p < 0.05). Blue edges represent positive correlation.

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  Figure 1. Locations of eye-related electrodes (1,8,17,25,32,126,127) from (a) a coronal view and (b) an axial view (the triangle standards for the position of the nose) with electrode numbers from the EGI 128-channel Hydro-Cel Geodesic system.

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  Figure 2. Event-related potentials (ERPs) averaged over all oddball (red) and standard (blue) trials across all participants in electrode Pz. For illustration purposes, the difference between the oddball and standard curves (black) was used to determine the P3 amplitude, P3 onset latency (solid triangle), and P3 peak latency (empty triangle) for each subject.

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  Figure 3. Relationship between the P3 parameters and task performance (number of correct responses and reaction time). The number of correct responses was correlated with (a) P3 amplitude and (b) P3 onset latency. Reaction time was correlated with (c) P3 amplitude and (d) P3 onset latency. Black squares are individual data points; solid red lines are linear regression lines; dotted red lines are 95% confidence intervals.

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  Figure 4. Relationship between P3 onset latency and global network properties derived from resting-state EEG. The rank of P3 onset latency was correlated with the rank of (a) mean function connectivity, (b) global efficiency, and (c) cluster coefficient. Black squares are individual data points; solid red lines are linear regression lines; dotted red lines are 95% confidence intervals.

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  Figure 5. Relationship between P3 onset latency (ms) and global network properties derived from resting-state ASL fMRI: P3 onset latency was correlated with (a) mean function connectivity, (b) global efficiency, (c) cluster coefficient, and (d) characteristic path length. Black squares are individual data points; solid red lines are linear regression lines; dotted red lines are 95% confidence intervals.

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  Figure 6. Relationship between P3 amplitude and global network properties derived from resting-state ASL fMRI. The rank of P3 amplitude was correlated with the rank of (a) mean function connectivity, (b) global efficiency, (c) cluster coefficient, and (d) characteristic path length. Black squares are individual data points; solid red lines are linear regression lines; dotted red lines are 95% confidence intervals.

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  Figure 7. Correlation of resting-state functional connectivity with P3 properties. Resting-state functional connectivity, measured with rsDASL, was significantly correlated with (a) P3 onset latency (p < 0.001) and (b) P3 amplitude (p < 0.001). Blue edges represent positive correlation, while red edges represent negative correlation.

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  Figure 8. Relationship between predicted P3 properties and observed P3 properties. Observed P3 onset latency was marginally correlated with predicted P3 onset latency (a) from the global rsFC and (b) from the rsFC over the most significant edges. Observed P3 amplitude was significantly correlated with predicted P3 amplitude (c) from the global rsFC and (d) from the rsFC over the most significant edges. Black squares are individual data points; solid red lines are linear regression lines; dotted red lines are 95% confidence intervals.