Key result
Cytotoxic treatment for testicular cancer increased the long-term risk of atherosclerotic disease compared with surgery alone (chemotherapy HR 2.6; 95% CI 1.1-5.9).
Why the study?
Do cytotoxic treatments for testicular cancer increase the long-term risk of cardiovascular disease compared to surgery alone or general population controls?
Cohort (n=1,980)
Yes
Do cytotoxic treatments for testicular cancer increase the long-term risk of cardiovascular disease compared to surgery alone or general population controls?
Effect estimate: HR 2.6 (95% CI 1.1 to 5.9)
Long-term survivors of testicular cancer treated with radiotherapy or cisplatin-based chemotherapy have a significantly increased risk of cardiovascular disease and cardiovascular risk factors compared to those treated with surgery alone or the general population.
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Supports closer atherosclerotic surveillance in survivors; leaves open whether risk is modifiable by regimen or prevention.
Haugnes et al. (2010) conducted a cohort in Testicular cancer (n=1,980). Cytotoxic treatment (radiotherapy and/or chemotherapy) vs. Surgery only or general population controls was evaluated on Atherosclerotic disease (HR 2.6, 95% CI 1.1 to 5.9). Cytotoxic treatment for testicular cancer increased the long-term risk of atherosclerotic disease compared with surgery alone (chemotherapy HR 2.6; 95% CI 1.1-5.9).
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