Cancer associated thrombosis: comparison of characteristics, treatment, and outcomes in oncological and non-oncological patients followed by Pulmonary Embolism Response Team

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Pulmonary embolism (n=235). Intervention: Oncologic status (Cancer) vs. Nononcologic status (No cancer). Primary outcome: Long-term mortality (HR 2.44, 95% CI 1.51-3.95, p=<0.001).

Resultado clave

Cancer was associated with a significantly increased risk of long-term mortality (HR 2.44) in patients with pulmonary embolism, despite similar in-hospital survival rates compared to nononcologic patients.

Diseño del estudio

Tipo

Cohort (n=235)

Multicéntrico

Sí

PICO estructurado

Does multidisciplinary PERT management yield different clinical outcomes in oncologic patients compared to nononcologic patients with pulmonary embolism?

Población

235 patients diagnosed with venous thromboembolism (pulmonary embolism) consulted by a local Pulmonary Embolism Response Team (PERT), including 81 oncologic patients (mean age 66.2, 48.1% male) and 154 nononcologic patients (mean age 57.4, 56.5% male).

Intervención

Multidisciplinary Pulmonary Embolism Response Team (PERT) management in oncologic patients

Comparador

Multidisciplinary Pulmonary Embolism Response Team (PERT) management in nononcologic patients

Resultado

In-hospital mortalityhard clinical

Multidisciplinary PERT management for pulmonary embolism in cancer patients achieves in-hospital survival rates comparable to non-cancer patients, though long-term mortality remains higher due to the underlying malignancy.

Resultado numérico

Estimación del efecto: HR 2.44 (95% CI 1.51-3.95)

Tasa de eventos absoluta: 12.8% vs 4.2%

valor p: p=<0.001

Limitaciones

Retrospective design
Small sample size
Large proportion of low- and intermediate-low risk patients
Data from a single PERT network
Lack of information regarding symptom duration and prior anticoagulation therapy
Inability to always determine the specific cause of death during follow-up

Resumen

DOI: 10.20452/pamw.16421, Published online: February 03, 2023, Authors: Arkadiusz Pietrasik1, Aleksandra Gąsecka1, Paweł Kurzyna1, Julia M. Smyk1, Marcin Wasilewski1, Rafał Wolański1, Katarzyna Wrona2, Szymon Darocha2, Dariusz Zieliński3, Marcin Grabowski1, Adam Torbicki2, Marcin Kurzyna2

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Cite This Study

Pietrasik et al. (Fri,) conducted a cohort in Pulmonary embolism (n=235). Oncologic status (Cancer) vs. Nononcologic status (No cancer) was evaluated on Long-term mortality (HR 2.44, 95% CI 1.51-3.95, p=<0.001). Cancer was associated with a significantly increased risk of long-term mortality (HR 2.44) in patients with pulmonary embolism, despite similar in-hospital survival rates compared to nononcologic patients.

synapsesocial.com/papers/6a12bea892637892a9a72ccf https://doi.org/https://doi.org/10.20452/pamw.16421

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