Key result
Coagulation disorders in solid tumors drive hypercoagulability linked to thromboembolism and poor treatment outcomes.
Why the study?
Coagulation disorders are significant complications in patients with solid tumors that worsen morbidity and mortality, making an understanding of their implications essential for optimizing patient management.
Understanding and managing coagulation disorders in patients with solid tumors is essential for optimizing treatment efficacy and clinical outcomes.
May inform perioperative risk stratification in solid tumors; leaves open optimal thromboprophylaxis strategies pending prospective data.
Coagulation disorders are increasingly recognized as significant complications in patients with solid tumors, affecting morbidity and mortality outcomes. Solid tumors can provoke a hypercoagulable state through the release of pro-coagulant factors, endothelial activation, and inflammation, leading to a heightened risk of coagulation disorders. These coagulation disorders may manifest as venous thromboembolism, arterial thromboembolism, thrombotic microangiopathy, or disseminated intravascular coagulation. These disorders can complicate surgical interventions and impact treatments, including chemotherapy and immunotherapy efficacy, leading to poor outcomes. Understanding the implications of coagulation disorders in solid tumors is essential for optimizing patient management, including identifying high-risk patients, implementing prophylactic measures, elucidating biomarkers for clinical outcomes, and exploring novel therapeutic agents. This review aims to provide insights into the current knowledge surrounding coagulation disorders in solid tumors and their clinical implications.
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Shapoo et al. (2025) conducted a review in Solid tumors and coagulation disorders. Coagulation disorders in solid tumors provoke hypercoagulable states leading to venous and arterial thromboembolism, which complicate surgical and medical treatments and lead to poor outcomes.
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