The frequency of mutant-specific cytotoxic T lymphocyte precursors (CTL-P) has been analyzed in several mouse strains. While H-2 antigens of responder strains have a limited influence on the frequency of major H antigen-specific CTL-P, the frequency of mutant-specific CTL-P can be equally as high in unrelated and related strains. In general, the frequency does not reflect the closeness of kinship between stimulator and responder.
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Boehmer et al. (1982) studied this question.
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