Key result
Dysregulation of TbCentrin4 in Trypanosoma brucei leads to the production of zoids (anucleate daughter cells), indicating its role in coordinating karyokinesis and cytokinesis.
TbCentrin4 is involved in coordinating karyokinesis and cytokinesis in Trypanosoma brucei.
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TbCentrin4 may guide antiparasitic strategies; leaves open validation in human-infective models before any clinical consideration.
Shi et al. (2008) studied Trypanosoma brucei biology. TbCentrin4 function analysis was evaluated. Dysregulation of TbCentrin4 in Trypanosoma brucei leads to the production of zoids (anucleate daughter cells), indicating its role in coordinating karyokinesis and cytokinesis.
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