Key result
Sleep disordered breathing contributes to the evolution and progression of atrial fibrillation through multiple pathways including mechanical and electrical remodeling, hypercapnia, and inflammation.
Why the study?
Does sleep disordered breathing contribute to the pathogenesis and progression of atrial fibrillation?
Does sleep disordered breathing contribute to the pathogenesis and progression of atrial fibrillation?
This review highlights the complex, multi-pathway interplay between sleep disordered breathing and the pathogenesis of atrial fibrillation.
This review illustrates the importance of sleep disordered breathing in evolution and progression of atrial fibrillation. While in early years associations were mainly attributed to the impact of hypoxemia and hypertension, nowadays multiple, additional pathways have been investigated or are currently under investigation. Sleep disordered breathing has been shown to have a direct impact on mechanical and electrical remodeling. In addition hypercapnia and negative intrathoracic pressure seem to alter atrial electrophysiology. Finally, impacts on inflammation and metabolic dysregulation display the complex interplay between breathing disorders and evolution and progression of atrial fibrillation.
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Bitter et al. (2013) conducted a review in Atrial Fibrillation and Sleep Disordered Breathing. Sleep disordered breathing contributes to the evolution and progression of atrial fibrillation through multiple pathways including mechanical and electrical remodeling, hypercapnia, and inflammation.
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