Key result
Patients with both obstructive sleep apnea and chronic obstructive pulmonary disease have higher sympathetic modulation of heart rate compared with those with either condition alone.
Why the study?
Do patients with both OSA and COPD have higher sympathetic modulation of heart rate compared to those with OSA or COPD alone?
Do patients with both OSA and COPD have higher sympathetic modulation of heart rate compared to those with OSA or COPD alone?
Patients with Overlap syndrome (OSA and COPD) exhibit higher cardiac sympathetic hyperactivity compared to either condition alone, providing a potential mechanism for their increased morbidity and mortality.
Does not warrant sympathetic assessment in overlap syndrome; leaves open mechanistic role in excess morbidity.
= 0.62, p = 0.007). These findings show that patients with both OSA and COPD have higher sympathetic modulation of heart rate compared with those with OSA or COPD alone. Furthermore, the findings provide a potential mechanism for the increased morbidity and mortality reported in patients suffering from both disorders, suggesting new therapeutic perspectives in Overlap syndrome.
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Taranto‐Montemurro et al. (2016) studied this question. Patients with both obstructive sleep apnea and chronic obstructive pulmonary disease have higher sympathetic modulation of heart rate compared with those with either condition alone.
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