Why the study?
Does cardiac output affect the initial arterial concentrations of propofol after short-infusion IV administration in a sheep model?
Does cardiac output affect the initial arterial concentrations of propofol after short-infusion IV administration in a sheep model?
Cardiac output is a significant determinant of the initial arterial concentrations of propofol, which may impact the pharmacokinetics of anesthesia induction.
No takes yet. Share an insight, caveat, or question.
May require propofol dose caution in low-output states; leaves open human pharmacokinetic validation.
Upton et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: