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We studied neutrophil-activating peptide-1/interleukin-8 in inflammatory bowel disease. 2. Mucosal levels of neutrophil-activating peptide-1/interleukin-8 were significantly higher in patients with active ulcerative colitis median 74.5 (range 17.7-450.8) pg/mg than in patients with active Crohn's disease 10.4 (4-46.9) pg/mg; P less than 0.002 or in normal control subjects 10.4 (4-16.6) pg/mg; P less than 0.002. 3. Circulating neutrophil-activating peptide-1/interleukin-8 was generally undetectable but there were higher levels of anti-neutrophil-activating peptide-1/interleukin-8 antibodies in patients with active ulcerative colitis 62.9 (3.4-239) ng/ml than in patients with active Crohn's disease 5.9 (2.1-18.10) ng/ml; P less than 0.001 or in control subjects 6.1 (3.2-15.8) ng/ml; P less than 0.001. 4. Neutrophil-activating peptide-1/interleukin-8 may be of specific functional importance in mediating inflammation in ulcerative colitis.
Mahida et al. (Sun,) studied this question.