Key result
A review of the molecular and ionic bases of regional cardiac electrical properties highlights their fundamental importance for investigating arrhythmia mechanisms and pharmacotherapy.
Understanding the regional differences in cardiac electrical properties is fundamental for investigating arrhythmia mechanisms and developing pharmacotherapy.
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Regional heterogeneities warrant inclusion in arrhythmia models and pharmacotherapy testing; extends molecular insights but leaves clinical translation open.
Optimal cardiac function depends on proper timing of excitation and contraction in various regions of the heart, as well as on appropriate heart rate. This is accomplished via specialized electrical properties of various components of the system, including the sinoatrial node, atria, atrioventricular node, His-Purkinje system, and ventricles. Here we review the major regionally determined electrical properties of these cardiac regions and present the available data regarding the molecular and ionic bases of regional cardiac function and dysfunction. Understanding these differences is of fundamental importance for the investigation of arrhythmia mechanisms and pharmacotherapy.
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Bartos et al. (2015) conducted a review in Cardiac function and arrhythmia. A review of the molecular and ionic bases of regional cardiac electrical properties highlights their fundamental importance for investigating arrhythmia mechanisms and pharmacotherapy.
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