The human body is designed for regular movement. Many humans, however, spend the bulk of their day sitting still instead. On average, for instance an adult spends approximately 10 hours each day sitting-in Asia, Europe as well as US. While a brief period of sitting here and there is natural, long periods of sitting day-in and day-out can seriously impact health and are associated with a significantly higher risk of heart disease, diabetes, obesity, cancer, and depression, as well as muscle and joint problems. Even working out vigorously may not compensate for long sitting sessions. The key is to build frequent movement variety into the day and to change the sitting position from time to time. About every 20--30 minutes the body needs a posture break by moving for a couple of minutes or, at least, by changing the sitting position.
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Matthias Wölfel (2017) studied this question.
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