Recurrence of Ph′-Positive Leukemia in Donor Cells after Marrow Transplantation for Chronic Granulocytic Leukemia

THE recurrence of leukemia in donor cells is a rare type of relapse after bone-marrow transplantation for acute leukemia, whether lymphoblastic or nonlymphoblastic. This phenomenon was first described in 1971,1 and since then additional cases have been reported — two of nonlymphoblastic2,3 and five of lymphoblastic leukemia.1,4 5 6 7 Disease recurred in the original cell line in five cases, and in morphologically different lines in two; all the patients were either in relapse or in an advanced stage of disease at the time of transplantation.We report a case of Ph′(Philadelphia chromosome)-positive leukemic relapse in donor cells after allogeneic marrow transplantation for . . .