Key result
Once-daily telmisartan 80 mg produced significantly greater reductions in the last 6-hour mean ambulatory systolic and diastolic blood pressure compared with ramipril 5 mg and 10 mg (P < 0.0001).
Why the study?
Does telmisartan 80 mg improve blood pressure reduction compared to ramipril 5-10 mg in patients with mild-to-moderate hypertension?
RCT (n=801)
Open-label, blinded-endpoint
randomly assigned
Does telmisartan 80 mg improve blood pressure reduction compared to ramipril 5-10 mg in patients with mild-to-moderate hypertension?
p-value: p=< 0.0001
Telmisartan 80 mg once daily provides superior 24-hour blood pressure control, particularly in the last 6 hours of the dosing interval, compared to ramipril up to 10 mg, with a lower incidence of cough.
No takes yet. Share an insight, caveat, or question.
Telmisartan 80 mg may be preferred for sustained 24-hour control; extends comparative ambulatory BP data versus ACEIs.
Williams et al. (2005) conducted an RCT in mild-to-moderate hypertension (n=801). telmisartan vs. ramipril 5 mg for 8 weeks then 10 mg for 6 weeks was evaluated on reduction from baseline in the last 6-h mean ambulatory systolic BP (SBP) and diastolic BP (DBP) (p=< 0.0001). Once-daily telmisartan 80 mg produced significantly greater reductions in the last 6-hour mean ambulatory systolic and diastolic blood pressure compared with ramipril 5 mg and 10 mg (P < 0.0001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: