In vitro evaluation of flexible pH and potassium ion-sensitive organic field effect transistor sensors

Acute myocardial ischemia is a state of trauma of the heart muscle caused by occlusion of oxygenated blood supply. It is accompanied by an increase in potassium and hydrogen ion concentrations in the heart muscles. A flexible substrate based ion-sensitive field effect transistor (ISFET) has been designed to measure the concentration of potassium and hydrogen ions with high specificity. Double exponential smoothing technique was used to calculate background noise and explain the dependence of drain current on reference voltage and ion concentration in saturation mode of the ISFET.