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Acetaldehyde may upregulate myocardial ANP in rats; leaves open its role in human alcoholic cardiomyopathy.
We studied the effects of ethanol and acetaldehyde on myocardial gene expression of atrial natriuretic peptide (ANP) and growth of rats. Combined ethanol and calcium carbimide treatment increased blood-acetaldehyde levels and ANP mRNA levels by 40-60% in 2-8 day experiments, compared to the controls. The results suggest a role for acetaldehyde in the development of alcoholic heart dysfunction.
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Heidi Jänkälä (2000) studied this question.
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