Key result
In a Thai registry of newly diagnosed non-valvular atrial fibrillation, incidence rates of ischemic stroke/systemic embolism, major bleeding, and death were 1.56, 2.26, and 4.17 per 100 person-years.
Why the study?
Clinical outcomes of patients with non-valvular AF in Asian populations may differ from non-Asians, leaving their incidence and predictors incompletely characterized.
What is the incidence of ischemic stroke/systemic embolism, major bleeding, and death in a contemporary Asian cohort of newly diagnosed non-valvular AF patients?
Cohort (n=3,405)
Yes
What is the incidence of ischemic stroke/systemic embolism, major bleeding, and death in a contemporary Asian cohort of newly diagnosed non-valvular AF patients?
In a contemporary Thai cohort of newly diagnosed non-valvular AF, the incidence rates of SSE, major bleeding, and death remain high, highlighting unmet needs in AF management.
BACKGROUND: Clinical outcomes of patients with non-valvular atrial fibrillation (AF) in Asian populations may be different from non-Asians. In this study, we aimed to determine the incidence of ischemic stroke/systemic embolism (SSE), major bleeding, and death, and the predictors for clinical outcomes in a contemporary Asian cohort of newly diagnosed AF patients. METHODS: This is a prospective multicenter nationwide registry of patients with AF from 27 hospitals in Thailand. Baseline data and follow-up data were collected every 6 months until 3 years. Data collections included demographic, medical history, laboratory, and medication details. Clinical outcomes were SSE, major bleeding, and all-cause mortality. Incidence rates for each clinical outcome were calculated and presented as rate per 100 person-years. Univariate and multivariate analysis was performed to determine the independent predictors for clinical outcomes. RESULTS: There was a total of 3405 patients: mean age was 67.8 ± 11.3 years, 1981 (58.2%) were male. During 30.8 ± 9.7 months follow-up, there was a total of 132 SSE (3.9%), 191 major bleeding (5.6%), and 357 all-cause deaths (10.5%). The incidence rates of SSE, major bleeding, and death were 1.56 (1.30-1.84), 2.26 (1.96-2.61), and 4.17 (3.33-4.25), per 100 person-years respectively. Independent predictors for clinical outcomes were age, type of AF, and the presence of comorbid conditions. CONCLUSION: The incidence rate of SSE, major bleeding, and death remains high reflecting the unmet needs in AF management.
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Krittayaphong et al. (2023) conducted a cohort in non-valvular atrial fibrillation (n=3,405). In a Thai registry of newly diagnosed non-valvular atrial fibrillation, incidence rates of ischemic stroke/systemic embolism, major bleeding, and death were 1.56, 2.26, and 4.17 per 100 person-years.
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