Key result
COVID-19 mRNA vaccine-linked myocarditis in 5 males features lateral LV edema and LGE with preserved LVEF.
Why the study?
Recent case series reported a possible association between acute myocarditis and COVID-19 vaccination, predominantly in young males.
What are the cardiovascular magnetic resonance findings in young adult patients with acute myocarditis following mRNA COVID-19 vaccination?
Case Report (n=5)
No
What are the cardiovascular magnetic resonance findings in young adult patients with acute myocarditis following mRNA COVID-19 vaccination?
Acute myocarditis following mRNA COVID-19 vaccination in young males presents with specific CMR abnormalities including lateral wall edema and LGE, reduced global longitudinal strain, and preserved LVEF, alongside a stable clinical course.
Answers are grounded in this paper and cite their sources.
Details CMR patterns in post-vaccine myocarditis cases; leaves open incidence, causality, and outcomes in larger cohorts.
BACKGROUND: Messenger RNA (mRNA) coronavirus disease of 2019 (COVID-19) vaccine are known to cause minor side effects at the injection site and mild global systemic symptoms in first 24-48 h. Recently published case series have reported a possible association between acute myocarditis and COVID-19 vaccination, predominantly in young males. METHODS: We report a case series of 5 young male patients with cardiovascular magnetic resonance (CMR)-confirmed acute myocarditis within 72 h after receiving a dose of an mRNA-based COVID-19 vaccine. RESULTS: Our case series suggests that myocarditis in this setting is characterized by myocardial edema and late gadolinium enhancement in the lateral wall of the left ventricular (LV) myocardium, reduced global LV longitudinal strain, and preserved LV ejection fraction. All patients in our series remained clinically stable during a relatively short inpatient hospital stay. CONCLUSIONS: In conjunction with other recently published case series and national vaccine safety surveillance data, this case series suggests a possible association between acute myocarditis and COVID-19 vaccination in young males and highlights a potential pattern in accompanying CMR abnormalities.
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Patel et al. (2021) conducted a case report in Acute myocarditis (n=5). mRNA COVID-19 vaccine was evaluated on Cardiovascular magnetic resonance (CMR) findings. Acute myocarditis following mRNA COVID-19 vaccination in 5 young males featured myocardial edema and late gadolinium enhancement in the lateral left ventricle with preserved ejection fraction.
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