Minoxidil and Improvement of Renal Function in Uremic Malignant Hypertension

Editorials1 November 1980Minoxidil and Improvement of Renal Function in Uremic Malignant HypertensionH. MITCHELL PERRY JR., M.D.H. MITCHELL PERRY JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-5-769 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe article by Mitchell and her colleagues in this issue (1) carries an important practical message: Severely compromised renal function associated with malignant hypertension can be improved by controlling the blood pressure with minoxidil. The report cites three patients, in a series of nine with malignant stages of hypertension, whose creatinine levels of 9 to 13 mg/dL before minoxidil treatment decreased by more than two thirds to 2 to 4 mg/dL during minoxidil treatment. (Note that the authors list four "improved patients," but in one the preminoxidil creatinine level was not very high and the decrease in serum creatinine was...References1. MITCHELLGRAHAMPETTINGER HRW. Renal function during long-term treatment of hypertension with minoxidil: comparison of benign and malignant hypertension. Ann Intern Med. 1980;93:676-81. LinkGoogle Scholar2. WAGENERKEITH HN. Diffuse arteriolar disease with hypertension and the associated retinal lesions. Medicine (Baltimore). 1939;18:317-430. CrossrefGoogle Scholar3. SCHOTTSTAEDTSOKALOW MM. The natural history and-course of hypertension with papilledema (malignant hypertension). Am Heart J. 1953;45:331-62. CrossrefMedlineGoogle Scholar4. PERRYSCHROEDER HH. The effect of treatment on mortality rates in severe hypertension: a comparison of medical and surgical regimens. Arch Intern Med. 1958; 102:418-25. CrossrefGoogle Scholar5. DAVIDOVMROCZEKGAVRILOVICHFINNERTY MWLF. Long term follow-up of aggressive medical therapy of accelerated hypertension with azotemia. Angiology. 1975;26:396-407. CrossrefGoogle Scholar6. MCCORMACKBELANDSCHNECKLOTHCORCORAN UJRA. Effects of antihypertensive treatment on the evaluation of the renal lesions in malignant nephrosclerosis. Am J Pathol. 1958;34:1011-21. MedlineGoogle Scholar7. PERRYCALOYEROPOULOSMOORE-JONES HAD. The course of treated malignant hypertension. In: BREST A, MOYER JH. Hypertension, Recent Advances. Philadelphia: Lea 1961:508. Google Scholar8. PERRYSCHROEDER HH. Studies on the control of hypertension: VI. Some evidence for reversal of the process during hexamethonium and hydralazine therapy. Circulation. 1956;13:528-36. CrossrefMedlineGoogle Scholar9. SCHROEDERMORROWPERRY HJH. Studies on the control of hypertension by hyphex: V. Effects on the course of the malignant stage. Circulation. 1954;10:321-30. CrossrefMedlineGoogle Scholar10. PERRYSCHROEDERCANTANZAROMOORE-JONESCAMEL HHFDG. Studies on the control of hypertension: VIII. Mortality, morbidity and remissions during twelve years of intensive therapy. Circulation. 1966;33:958-72. CrossrefMedlineGoogle Scholar11. PERRYCALOYEROPOULOSMOORE-JONES HAD. Therapy of severe hypertension complicated by renal failure. Am J Cardiol. 1962;9:908-15. CrossrefMedlineGoogle Scholar12. . Return of elevated blood pressure after withdrawal of antihypertensive drugs. Circulation. 1975;51:1107-13. CrossrefMedlineGoogle Scholar13. THURMSMITH RW. On resetting of "barostats" in hypertensive patients. JAMA. 1967;201:301-4. CrossrefMedlineGoogle Scholar14. PERRYCAMELCARMODYAHMEDPERRY HGSKE. Survival in hydralazine-treated hypertensive patients with and without late toxicity. J Chronic Dis. 1977;30:519-28. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington University School of Medicine St. Louis, Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOn the Natural Tendency to Progressive Loss of Remaining Kidney Function in Patients with Impaired Renal FunctionPathophysiology, clinical aspects, and treatment of hypertensive crisesPruritic Rash with Actinic Keratosis and Impending Exfoliation in a Patient with Hypertension Managed with MinoxidilHypertensive CrisesMinoxidil in Uremic Malignant HypertensionEDUARDO PODJARNY, M.D., KEEV KORZETS, M.B., B.S., JACQUES BERNHEIM, M.D. 1 November 1980Volume 93, Issue 5Page: 769-771KeywordsBlood pressureCreatinineHypertension Issue Published: 1 November 1980 PDF downloadLoading ...