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May 25, 2026European Journal of Pharmaceutical SciencesOpen Access

Impact of porcine skin processing on in vitro permeation testing: implications for reliable evaluation of topical metformin delivery

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Authors

CZCelina ZhaoJZJianying ZhangVPVasyl Pastukh

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Overview

Randomized trial investigates how porcine skin sourcing affects drug permeation in topical formulations, indicating the need for standardized methods.

Key Points

  • This study evaluates how processing methods for porcine skin impact the delivery of metformin through its barrier.
  • Evaluated drug permeation using Franz diffusion cells over 48 hours.
  • Assessments included histological examination of skin barrier structure.
  • Compared skin sourced from butcher shops and slaughterhouses.
  • Skin from butcher shops showed a 20-60-fold increase in drug flux within 2 hours.
  • Cumulative permeation reached approximately 80% of the applied dose at 48 hours in processed skin.
  • Unprocessed skin maintained barrier function with less than 30% cumulative permeation.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a13e6480e02ee3982d31619https://doi.org/10.1016/j.ejps.2026.107564
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