Dental and Masticatory Outcomes of 3D-Printed Mandibular Advancement Appliance Therapy in Obstructive Sleep Apnea

Of Significance: This study is the first to integrate objective assessment of masticatory efficiency with three-dimensional digital quantification of dental movement in patients undergoing long-term mandibular advancement appliance (MAA) therapy for Obstructive Sleep Apnea (OSA).By combining functional and morphological analyses, it provides a comprehensive understanding of the dental and functional consequences of this treatment.The findings demonstrate that customized, 3D-printed MAAs can achieve clinical efficacy comparable to CPAP in improving oxygen desaturation and snoring, without inducing significant occlusal alterations or impairing masticatory performance over one year.These results highlight the potential of digital workflows to enhance the safety and precision of oral appliance therapy, with implications for patient adherence, long-term oral health, and cost-effective management of OSA within sleep medicine.