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May 1, 2026Journal of Drug Delivery Science and TechnologyOpen Access

Quality by Design Optimization of Curcumin-Loaded Solid Lipid Nanoparticles@PVA-Alginate Hydrogel-Based Chronic Wound Dressings

Zenayda Aguilar-Jiménez Barbara Blanco-Fernandez Ángel Concheiro Carmen Alvarez-Lorenzo

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Key Points

The aim is to develop and optimize a hydrogel-based system for delivering curcumin using solid lipid nanoparticles.
Developed a hydrogel–SLN–curcumin platform using quality by design principles.
Utilized green, low-energy methods for stable and reproducible fabrication.
Evaluated drug loading efficiency and hydrogel properties, including swelling and pH responsiveness.
Optimized SLNs achieved a size of 53 nm with a drug encapsulation efficiency of 99.5%.
Hydrogels demonstrated excellent swelling and adhesion properties.
The system enabled controlled curcumin release and exhibited pro-angiogenic potential.

Implication

Study optimized curcumin delivery in chronic wound dressings, indicating enhanced healing potential.

Discussion

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Cite This Study

Aguilar-Jiménez et al. (2026) studied this question.

synapsesocial.com/papers/6a13e6ee0e02ee3982d31ada https://doi.org/10.1016/j.jddst.2026.108510

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