The aim is to evaluate cyclic peptides as effective carriers for delivering the anti-tuberculosis drug pyrazinamide to difficult-to-reach tissue areas.
Cyclic peptides were synthesized and tested for drug encapsulation efficiency.
In vitro and in vivo assays were conducted to assess drug delivery efficacy and tissue penetration.
Statistical analyses were performed to compare treatment outcomes.
Cyclic peptides improved delivery of pyrazinamide to targeted tissues, enhancing drug availability.
The treatment group showed a 30% increase in drug concentration in tissues compared to controls (p<0.05).
No significant adverse effects were observed in the treated cohorts.
Abstract
One of the important goals of drug delivery in the treatment of diseases is to effectively deliver drugs to deep and inaccessible areas of tissues. In recent years, cyclic peptides...