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May 25, 2026Open Access

Co-inheritance of Alpha & Beta-Thalassemia: Case Report of a Bangladeshi Individual

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Authors

MHMaruf Al HasanTNTamanna Nourin

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Overview

Case report reveals diagnostic challenges and management for a patient with alpha and beta-thalassemia co-inheritance, indicating the need for genetic counselling.

Key Points

  • To discuss the rare case of co-inheritance of alpha and beta-thalassemia and its implications for diagnosis and treatment.
  • Examined a 26-year-old female patient with a history of weakness and lethargy.
  • Conducted haematological studies and genetic tests to confirm thalassemia types.
  • Recommended management and genetic counselling for the patient and family.
  • The patient exhibited severe anemia with a hemoglobin level of 7.40 g/dL and elevated serum ferritin at 1210.94 ng/mL.
  • Hb electrophoresis indicated beta thalassemia minor with 5.3% haemoglobin A2, above the reference range.
  • Genetic tests confirmed heterozygous states for alpha (SEA) and beta (cd15) thalassemia.

Cite This Study

Hasan et al. (2024) studied this question.

synapsesocial.com/papers/6a13e83b0e02ee3982d32ef7https://doi.org/10.37545/haematoljbd2024117
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Compound Heterozygous of Hb E and Beta Thalassemia Independent of Transfusion: A Rare Case Report2024
  2. 2Prenatal Diagnosis of Compound Heterozygous Beta-Thalassemia: A Report of Two Cases2026
  3. 3Compound heterozygosity for Southeast Asian hereditary persistence of fetal hemoglobin and β0-thalassemia results in thalassemia intermedia: Pedigree analysis and genetic research in a family from South China. A case report2024
  4. 4Co-inheritance of hemoglobin D-Punjab and beta thalassemia: Familial case study highlighting the clinical relevance and the need for premarital screening2026
  5. 5Severe Transfusion-Dependent Thalassemia in Compound Heterozygote Palestinian Siblings with Two α-Globin Gene Defects, Hb Taybe D <i>HBA1</i> : C.119_121delCCA Mutation and <i>HBA2</i> : C.*94A &gt; G Mutation2024