NT-proBNP and hs-CRP levels were significantly inversely correlated with right ventricular fractional area change (r=-0.55, P=0.001 and r=-0.58, P<0.001) in adults with repaired Tetralogy of Fallot.
Observational (n=32)
Do NT-proBNP and hs-CRP levels correlate with echocardiographic parameters of right ventricular dysfunction in adults with repaired Tetralogy of Fallot?
NT-proBNP and hs-CRP levels significantly correlate with right ventricular systolic dysfunction in adults with repaired Tetralogy of Fallot, suggesting their utility as biomarkers for risk stratification.
Effect estimate: r = -0.55 (NT-proBNP); r = -0.58 (hs-CRP)
p-value: p=0.001 (NT-proBNP); <0.001 (hs-CRP)
A BSTRACT Introduction: Repaired TOF (rTOF) is a common condition in adult congenital heart disease care. The aim of this article is to investigate how inflammatory markers and volume overload affect rTOF, and how these factors correlate with echocardiographic findings in the right heart cavities. Methods: This study included 32 adult patients (mean age, 27.44 ± 6.22 years) who had undergone surgical correction of TOF during infancy. All participants underwent transthoracic echocardiography, and laboratory assessments included measurements of N-terminal pro-B-type natriuretic peptide (NT-proBNP; reference range ≤125 pg/mL) and high-sensitivity C-reactive protein (hs-CRP; reference range ≤2.0 mg/L). Results: Significant correlations were found between NT-proBNP levels and right ventricular (RV) fractional area change (FAC) (r = −0.55, P = 0.001), tricuspid annular plane systolic excursion (TAPSE) (r = −0.35, P = 0.04), RV basal diameter (r = 0.47, P = 0.006), and right atrium (RA) area (r = 0.50, P = 0.003). Similarly, hs-CRP levels showed strong associations with RV FAC (r = −0.58, P < 0.001), TAPSE (r = −0.45, P = 0.009), RV basal diameter (r = 0.43, P = 0.01), and RA area (r = 0.43, P = 0.01). NT-proBNP had a significant impact ( P = 0.017; EXP B = 0.982) on RV FAC. A decrease of 10 units in NT-proBNP was associated with a 17% reduction likelihood of having RV FAC <35%. Conclusion: The proinflammatory response (hs-CRP) and volume load (NT-proBNP) are directly correlated with echocardiographic parameters of the right heart cavities in patients with rTOF, suggesting that patients may benefit from treatment with anti-inflammatory drugs, as well as medications targeting diastolic dysfunction.
Đozić et al. (2026) conducted an observational in Repaired Tetralogy of Fallot (rTOF) (n=32). NT-proBNP and hs-CRP was evaluated on Correlation of NT-proBNP and hs-CRP with right ventricular fractional area change (RV FAC) (r = -0.55 (NT-proBNP); r = -0.58 (hs-CRP), p=0.001 (NT-proBNP); <0.001 (hs-CRP)). NT-proBNP and hs-CRP levels were significantly inversely correlated with right ventricular fractional area change (r=-0.55, P=0.001 and r=-0.58, P<0.001) in adults with repaired Tetralogy of Fallot.