Pregnant women of advanced maternal age exhibited higher arterial stiffness, greater carotid intima-media thickness, and impaired autonomic regulation compared with younger pregnant women.
Observational
Does advanced maternal age impact vascular and autonomic function during pregnancy and postpartum compared to younger pregnant women?
Advanced maternal age is associated with early subclinical vascular and autonomic changes during pregnancy, which may predispose these women to pregnancy-related complications.
This study assessed the impact of advanced maternal age (AMA) on vascular and autonomic function across all three trimesters. Compared with younger pregnant women, women of AMA exhibited higher arterial stiffness and greater carotid intima-media thickness, and impaired autonomic regulation throughout pregnancy, despite no significant difference in endothelial function. These observed differences may represent early subclinical changes in AMA women, which may bring them closer to a physiological threshold where complications may occur.
Lee et al. (Mon,) conducted a observational in Pregnancy. Advanced maternal age vs. Younger pregnant women was evaluated on Vascular and autonomic function (arterial stiffness, carotid intima-media thickness, autonomic regulation). Pregnant women of advanced maternal age exhibited higher arterial stiffness, greater carotid intima-media thickness, and impaired autonomic regulation compared with younger pregnant women.