Key result
Preconception and early pregnancy cardiovascular function did not differ between women who had a viable pregnancy and those who had a first trimester miscarriage.
Why the study?
Are there differences in preconception and early pregnancy cardiovascular function between women who have a viable pregnancy and those who have a first trimester miscarriage?
Population
172 healthy women with recorded pregnancies recruited prior to natural conception at a single maternity…
Design
Cohort
Follow-up
From pre-pregnancy to 6 weeks gestation
Authors
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Miscarriage may represent independent future CVD risk rather than preconception dysfunction; leaves open mechanistic pathways for prospective study.
Cohort (n=367)
No
Are there differences in preconception and early pregnancy cardiovascular function between women who have a viable pregnancy and those who have a first trimester miscarriage?
Pre-pregnancy and early pregnancy haemodynamic and arterial function do not differ between women who subsequently miscarry and those with viable pregnancies, suggesting that miscarriage may be an independent risk event for future cardiovascular disease rather than a reflection of pre-existing dysfunction.
Foo et al. (2017) conducted a cohort in Pregnancy viability and first trimester miscarriage (n=367). First trimester miscarriage vs. Viable pregnancy was evaluated on Baseline cardiovascular function (cardiac output, peripheral vascular resistance, pulse wave velocity, aortic augmentation index) and pregnancy adaptation. Preconception and early pregnancy cardiovascular function did not differ between women who had a viable pregnancy and those who had a first trimester miscarriage.
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