Genetic studies play a pivotal role in the diagnosis of inherited arrhythmogenic diseases and may help in the management of patients and their relatives to prevent sudden cardiac death.
Up to 14,500 young individuals die suddenly every year in Europe of cardiac pathologies. The majority of these tragic events are related to a group of genetic defects that predispose the development of malignant arrhythmias (inherited arrhythmogenic diseases IADs). IADs include both cardiomyopathies (hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy) and channelopathies (long QT syndrome, short QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia). Every time an IAD is identified in a patient, other individuals in his/her family may be at risk of cardiac events. However; if a timely diagnosis is made, simple preventative measures may be applied. Genetic studies play a pivotal role in the diagnosis of IADs and may help in the management of patients and their relatives.
Mazzanti et al. (Thu,) conducted a review in Sudden cardiac death in the young and inherited arrhythmogenic diseases. Genetic studies was evaluated. Genetic studies play a pivotal role in the diagnosis of inherited arrhythmogenic diseases and may help in the management of patients and their relatives to prevent sudden cardiac death.