Key result
Acute hyperinsulinemia increases muscle sympathetic nerve activity by ~32%, driven by peripheral vasodilation.
Why the study?
Does hyperinsulinemia increase muscle sympathetic nervous system activity via the arterial baroreflex in adult humans?
Does hyperinsulinemia increase muscle sympathetic nervous system activity via the arterial baroreflex in adult humans?
Peripheral vasodilation induced by insulin contributes to increased muscle sympathetic nervous system activity during hyperinsulinemia via the arterial baroreflex.
Answers are grounded in this paper and cite their sources.
Hyperinsulinemia raises MSNA without baroreflex change; hypothesis-generating for vasodilation-mediated sympathetic effects in metabolic disease.
We hypothesized that elevation in muscle sympathetic nervous system activity (MSNA) during hyperinsulinemia is mediated by its peripheral vasodilator effect on the arterial baroreflex. Using three separate protocols in humans, we observed increases in both MSNA and cardiac output during hyperinsulinemia, which we attributed to the baroreflex response to peripheral vasodilation induced by insulin. Results show that peripheral vasodilation induced by insulin contributes to increased MSNA during hyperinsulinemia.
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McMillan et al. (2022) studied Healthy adults (n=33). Intravenous insulin infusion vs. Baseline was evaluated on Muscle sympathetic nerve activity (MSNA) burst incidence (bursts/100 heartbeats) (p=<0.01). Acute hyperinsulinemia increased muscle sympathetic nerve activity from 31 to 41 bursts/100 heartbeats without changing arterial baroreflex sensitivity, an effect attributed to peripheral vasodilation.
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