What question did this study set out to answer?

To investigate the prospective association between the duration and treatment of hypertension and the occurrence of cerebral white matter lesions.

March 1, 2002BrainOpen Access

Hypertension and cerebral white matter lesions in a prospective cohort study

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Authors

FLF.‐E. de LeeuwUniversity Medical Center Utrecht JGJan Cees de GrootCardiac Imaging MOMatthijs OudkerkCardiac Imaging

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Implication

Prospective cohort study shows hypertension duration increases cerebral white matter lesions in older adults, indicating effective blood pressure control reduces risk.

Key Points

To investigate the prospective association between the duration and treatment of hypertension and the occurrence of cerebral white matter lesions.
Randomly sampled 1,077 participants aged 60 to 90 years from two prospective population-based cohort studies with baseline blood pressure measured in 1975–1978 or 1990–1993.
Assessed brain pathology using 1.5 T cerebral MRI scanning, rating subcortical and periventricular white matter lesions separately.
Participants aged 60–70 years with >20 years of hypertension had markedly elevated risks for subcortical lesions (RR 24.3, 95% CI 5.1–114.8) and periventricular lesions (RR 15.8, 95% CI 3.4–73.5) compared to normotensive individuals.
Successfully treated hypertensive participants showed lower relative risks for subcortical (RR 3.3, 95% CI 1.3–8.4) and periventricular lesions (RR 2.6, 95% CI 1.0–6.8) than poorly controlled hypertensive participants (subcortical RR 8.4, 95% CI 3.1–22.6; periventricular RR 5.8, 95% CI 2.1–16.0).

Cite This Study

Leeuw et al. (2002) studied this question.

synapsesocial.com/papers/6a143ba73f92ec2dd759c01b https://doi.org/10.1093/brain/awf077

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Implication

Prospective cohort study shows hypertension duration increases cerebral white matter lesions in older adults, indicating effective blood pressure control reduces risk.

Hypertension and cerebral white matter lesions in a prospective cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

Hypertension and cerebral white matter lesions in a prospective cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider