What does this research mean for the field?

Propofol increases systemic vascular capacitance and induces hypotension primarily through the inhibition of sympathetic vasoconstrictor activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1998AnesthesiologyOpen Access

Propofol-induced Increase in Vascular Capacitance Is Due to Inhibition of Sympathetic Vasoconstrictive Activity

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Why the study?

Does propofol increase systemic vascular capacitance via inhibition of sympathetic vasoconstrictor activity in anesthetized rats?

Structured PICO

Does propofol increase systemic vascular capacitance via inhibition of sympathetic vasoconstrictor activity in anesthetized rats?

Population

33 Wistar rats previously anesthetized with urethane and ketamine

Intervention

Propofol bolus administration of 2, 10, and 20 mg/kg

Comparator

Control state (before propofol infusion) across four groups: intact, sympathetic nervous system (SNS)-block (hexamethonium infusion), SNS-block + noradrenaline (NA), and hypovolemic

Outcome

Mean circulatory filling pressure (Pmcf) and mean arterial pressure (MAP) measured 2 min after bolus administrationsurrogate

Propofol-induced hypotension is partly mediated by an increase in systemic vascular capacitance resulting from sympathetic nervous system inhibition.

Discussion

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Implication

Indicates SNS inhibition mediates propofol venodilation in rats; hypothesis-generating for human hypotension mechanisms.

Cite This Study

Hoka et al. (1998) studied this question.

synapsesocial.com/papers/6a145678a4182367b162bebd https://doi.org/10.1097/00000542-199812000-00028

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Propofol-induced Increase in Vascular Capacitance Is Due to Inhibition of Sympathetic Vasoconstrictive Activity

Structured PICO

Discussion

Implication

Cite This Study

Propofol-induced Increase in Vascular Capacitance Is Due to Inhibition of Sympathetic Vasoconstrictive Activity

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider