The outcomes of valve-in-valve TMVR for patients with mitral bioprosthetic valve dysfunction: a single-center retrospective study

Objective To explore the clinical efficacy and follow-up results of the valve-in-valve transcatheter mitral valve replacement (TMVR) technique in patients with mitral bioprosthetic valve dysfunction. Methods The medical data of patients with biological valve dysfunction after mitral valve replacement who underwent TMVR in our hospital from January 2019 to January 2024 were retrospectively collected. The echocardiography data, New York Heart Association (NYHA) grade, EuroQol visual analogue scale (EQ-VAS) score, and 6-minute walking distance before and after the operation were compared. Results A total of 33 patients, 8 males and 25 females, with an average age of 70.70 ± 9.04 years, were included in this study. All 33 patients underwent TMVR surgery successfully. Seven patients underwent surgery via the atrial septal approach, and 26 patients underwent surgery via the apical approach. The success rate of the TMVR was 100.0%. One patient had a complication of cerebral infarction and eventually died 7 days after the operation. Compared with those prior to the operation, the NYHA grade, EQ-VAS score and the 6-minute walking distance were improved significantly at follow-up (all P < 0.05). Conclusion Valve-in-valve TMVR is a feasible option for patients with degenerated bioprosthetic mitral valves. However, follow-up studies are still needed to determine the long-term effects.