Key result
Arterial stiffness was the strongest hemodynamic determinant of systolic blood pressure in older adults, while total peripheral resistance was the primary determinant of mean arterial pressure.
Cross-Sectional (n=3,762)
Yes
In older adults, systolic blood pressure is primarily driven by arterial stiffness, whereas mean arterial pressure is predominantly determined by total peripheral resistance.
Supports stiffness-focused SBP evaluation in older adults; extends hemodynamic models but leaves causal outcome effects open.
The primary aim of the present study was to identify the hemodynamic correlates of both steady and pulsatile blood pressure (BP) in community-dwelling older adults. In 3762 adults aged 70 to 89 years, significant hemodynamic determinants of both brachial and carotid systolic BP included arterial stiffness as measured by aortic pulse wave velocity, stroke volume (via echocardiography), arterial wave reflection, left ventricular ejection time, and upstroke time. The strongest influence was exerted by arterial stiffness. The steady-state component of blood pressure, mean arterial pressure, was associated with both cardiac index and total peripheral resistance (TPR), but was more strongly associated with TPR. Results were similar when participants taking antihypertensive medications were excluded from analyses. The overall findings suggest that mean arterial pressure is associated strongly with TPR and that significant hemodynamic correlates of systolic BP included arterial stiffness, stroke volume, and arterial wave reflection.
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Tanaka et al. (2016) conducted a cross-sectional in Blood pressure in older adults (n=3,762). Arterial stiffness was the strongest hemodynamic determinant of systolic blood pressure in older adults, while total peripheral resistance was the primary determinant of mean arterial pressure.
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