Key result
Men undergoing TAVI show ~13% lower 30-day mortality than women but higher one-year mortality and PVL.
Why the study?
The study was conducted to assess whether differences exist between men and women in common postoperative complications and survival after transcatheter aortic valve implantation.
Does male gender affect postoperative complications and survival in patients undergoing transcatheter aortic valve implantation?
Population
92,499 patients (43,948 men and 48,551 women) across 24 studies
Comparison
Men vs women undergoing transcatheter aortic valve implantation
Design
Systematic review and meta-analysis
Follow-up
One-year
Authors
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Sex differences in TAVI mortality and leak risk warrant sex-specific counseling; leaves open whether targeted strategies can mitigate longer-term disparities in men.
Meta-Analysis (n=92,499)
Does male gender affect postoperative complications and survival in patients undergoing transcatheter aortic valve implantation?
Effect estimate: RR 0.87 (95% CI 0.81 to 0.93)
p-value: p=0.0001
In patients undergoing TAVI, men have a lower risk of short-term complications (bleeding, vascular, stroke) and 30-day mortality, but a higher risk of paravalvular leak and 1-year mortality compared to women.
Lang et al. (2023) conducted a meta-analysis in Severe aortic valve stenosis (n=92,499). Male gender (Transcatheter Aortic Valve Implantation) vs. Female gender was evaluated on Thirty-day mortality (RR 0.87, 95% CI 0.81 to 0.93, p=0.0001). Men undergoing transcatheter aortic valve implantation had a significantly lower risk of thirty-day mortality (RR 0.87) compared to women, but a higher risk of one-year mortality (RR 1.20) and paravalvular leak (RR 1.42).
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