The presence of dissociated pulmonary vein electrical activities after circumferential antrum ablation was associated with a significantly lower rate of atrial fibrillation recurrence (P=0.023).
Cohort (n=196)
Does the presence of dissociated pulmonary vein electrical activities after circumferential antrum PV ablation predict reduced AF recurrence in patients with paroxysmal AF?
The presence of dissociated pulmonary vein electrical activities after circumferential PV antrum ablation identifies a subgroup of paroxysmal AF patients with a higher initial procedural success rate and lower long-term AF recurrence.
p-value: p=0.023
BACKGROUND: The incidence and clinical implication of dissociated pulmonary vein (PV) electrical activities after circumferential antrum PV ablation for paroxysmal atrial fibrillation (AF) remains unclear. METHODS AND RESULTS: A total of 196 patients with symptomatic paroxysmal AF who underwent circumferential antrum PV ablation were prospectively studied. Dissociated PV electrical activities were observed in 101 patients (Group 1), but absent in the remaining 95 patients (Group 2). There were no significant differences in the baseline clinical characteristics between them, except that Group 2 had a higher prevalence of hypertension (30 vs. 44%, P = 0.04). After 21.8 ± 7.9 months of follow-up, 148 had no recurrence of AF after the initial procedure. AF recurrence rate was significantly higher in Group 2 than in Group 1 (P = 0.023). Relapse of PV conduction was the major cause of AF recurrence in both groups (16/16 vs. 19/23, P = 0.08), and the overall procedural success rate after the redo ablation procedure was similar in the 2 groups (90 vs. 86%, P = 0.44). However, the total number of patients with non-PV foci was significantly higher in Group 2 than in Group 1 (12/95 vs. 2/101, P < 0.01). CONCLUSIONS: Dissociated PV electrical activities might identify a subgroup of patients with relatively higher initial procedural success with circumferential PV antrum ablation.
Chen et al. (Mon,) conducted a cohort in Symptomatic paroxysmal atrial fibrillation (n=196). Presence of dissociated pulmonary vein electrical activities vs. Absence of dissociated pulmonary vein electrical activities was evaluated on Atrial fibrillation recurrence (p=0.023). The presence of dissociated pulmonary vein electrical activities after circumferential antrum ablation was associated with a significantly lower rate of atrial fibrillation recurrence (P=0.023).