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Comparative review highlights frontal lesion predominance in incidental low-grade gliomas, suggesting clinical implications.
) were analyzed. A within-(iLGG) group analysis on the number of lesions per area showed a significant predominance of frontal lobe lesions (p < 0.001), and an equal involvement of the left and right hemisphere (p = 0.470). The most frequent reason for MRI was headache. A between-(iLGG vs. sLGG) group analysis showed an increased proportion of frontal lesions in the iLGGs vs. sLGGs (Z = -2.693, p = 0.006). The MRI subtraction analyses (iLGG vs. sLGG) confirmed a more prevalent frontal location in iLGG vs. sLGG. The number of oligodendroglioma were highly correlated with the number of frontal (p < 0.001) lesions. In the present exploratory study many patients with iLGG have frontal lesions to a greater extent than in sLGG. We discuss the clinical implications of this neuroanatomical pattern.
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Tomasino et al. (2026) studied this question.
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