Injectable hydrogel with sequential drug release for synergistic antibacterial activity and osteogenesis in infected bone defects

Shouye Sun; Zhaochangci Chen; Qian Wang; Yutao Cui; Hang Xu; Baoming Yuan; Wang Yangbing; Dankai Wu; Chuangang Peng

doi:10.1016/j.matdes.2026.116275

May 1, 2026Materials & DesignOpen Access

Injectable hydrogel with sequential drug release for synergistic antibacterial activity and osteogenesis in infected bone defects

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Key Points

To evaluate the efficacy of an injectable hydrogel with sequential drug release for repairing infected bone defects.
Utilized antibiotic-free PEG/ODEX hydrogel for treatment.
Implemented sequential release of lysozyme and BMP-2-derived peptide.
Applied in a murine femoral infected bone defect model.
Achieved significant bactericidal effects with the hydrogel.
Demonstrated pro-osteogenic activity with increased bone regeneration.
Improved outcomes were observed compared to controls.

Implication

Demonstrates enhanced bone regeneration in infected bone defects, suggesting promising therapeutic use.

Abstract

• Antibiotic-free injectable PEG/ODEX hydrogel for infected bone defect repair. • Sequential release of lysozyme and BMP-2-derived peptide via the hydrogel system • Synergistic bactericidal effect and pro-osteogenic activity of the bifunctional hydrogel. • Enhanced bone regeneration in murine femoral infected bone defect model.

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Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a15384cb5d9c58d83e8c5e9 https://doi.org/10.1016/j.matdes.2026.116275

View Full Paper

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Injectable hydrogel with sequential drug release for synergistic antibacterial activity and osteogenesis in infected bone defects

Key Points

Implication

Abstract

Discussion

Cite This Study

Injectable hydrogel with sequential drug release for synergistic antibacterial activity and osteogenesis in infected bone defects

Key Points

Implication

Abstract

Discussion

Cite This Study

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