Key result
Blue-collar occupation was associated with the lowest mean flow-mediated dilation (4.01%) compared to management/professional (4.97%), sales/office (5.19%), and services (4.73%) (P<0.001).
Why the study?
Are work hours, job strain, and occupational category associated with endothelial function (brachial artery flow-mediated dilation)?
Cross-Sectional (n=1,499)
Are work hours, job strain, and occupational category associated with endothelial function (brachial artery flow-mediated dilation)?
Absolute Event Rate: 4.01% vs 4.97%
p-value: p=< 0.001
Occupational category is significantly associated with endothelial function, with blue-collar workers exhibiting lower flow-mediated dilation, which may contribute to occupational disparities in cardiovascular disease.
Occupational category links to endothelial function; hypothesis-generating for CVD disparities and should not yet change practice or guidelines.
OBJECTIVE: To investigate associations of work hours, job control, job demands, job strain, and occupational category with brachial artery flow-mediated dilation (FMD) in 1499 Multi-Ethnic Study of Atherosclerosis participants. METHODS: Flow-mediated dilation was obtained using high-resolution ultrasound. Mean values of FMD were examined across categories of occupation, work hours, and the other exposures using regression analyses. RESULTS: Occupational category was significantly associated with FMD overall, with blue-collar workers showing the lowest mean values-management/professional = 4.97 ± 0.22%; sales/office = 5.19 ± 0.28%; services = 4.73 ± 0.29%; and blue-collar workers = 4.01 ± 0.26% (adjusted P < 0.001). There was evidence of effect modification by sex (interaction P = 0.031)-significant associations were observed among women (adjusted P = 0.002) and nearly significant results among men (adjusted P = 0.087). Other exposures were not significantly associated with FMD. CONCLUSIONS: Differences in endothelial function may account for some of the variation in cardiovascular disease across occupational groups.
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Charles et al. (2014) conducted a cross-sectional in Endothelial function (n=1,499). Occupational category (blue-collar) vs. Other occupational categories (management/professional, sales/office, services) was evaluated on Brachial artery flow-mediated dilation (FMD) (p=< 0.001). Blue-collar occupation was associated with the lowest mean flow-mediated dilation (4.01%) compared to management/professional (4.97%), sales/office (5.19%), and services (4.73%) (P<0.001).
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