Randomized trial investigates PCDH9 and EMT markers in ccRCC, suggesting new prognostic insights.
Key Points
This study aims to explore the expression patterns and prognostic significance of PCDH9 and other EMT markers in clear cell renal cell carcinoma (ccRCC).
Immunofluorescence analysis on tissue sections from 48 ccRCC patients
Utilization of TCGA-KIRC dataset for validation and survival analyses
Correlation examinations between PCDH9 and various EMT markers
PCDH9 mRNA was significantly downregulated in ccRCC tumors (p<0.001)
High PCDH9 and CTNNB1 were associated with improved overall survival (HR 0.6, 95% CI 0.4-0.8, p=0.002)
VIM predicted disease progression independently (HR 1.5, 95% CI 1.1-2.0, p=0.030)